• 產(chǎn)品描述：

  MYF-01-37 是一種共價(jià) TEAD 抑制劑，靶向 Cys380。MYF-01-37 可逆地抑制 YAP/TEAD 相互作用。

• 靶點(diǎn)： YAP

• 體外研究：
  MYF-01-37 (10 μM; 24h) results in inhibition of direct YAP/TEAD interaction in HEK 293T cells, and in the reduction in canonical YAP target gene CTGF expression in PC-9 cells[1].
  MYF-01-37 (0.1, 1, 10, 100 μM) has minimal impact on cell viability of several EGFR-mutant NCSLC cell lines[1].
  MYF-01-37 (10 μM; 10 days) combinated with OT (combination of osimertinib and trametinib) leads to a dramatic decrease in dormant cells compared to OT alone[1].

• 參考文獻(xiàn)：
  [1]. Kari J Kurppa, et al. Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. Cancer Cell. 2020 Jan 13;37(1):104-122.e12. [Content Brief]

• 溶解性： DMSO  :  250  mg/mL  (838.08  mM;  Need  ultrasonic)

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.352 ml	16.762 ml	33.523 ml
  5 mM	0.67 ml	3.352 ml	6.705 ml
  10 mM	0.335 ml	1.676 ml	3.352 ml
  50 mM	0.067 ml	0.335 ml	0.67 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *